SINGLE-CELL MAPPING OF PERIPHERAL BLOOD MONONUCLEAR CELLS REVEALS KEY TRANSCRIPTOMIC CHANGES FAVORING CORONARY ARTERY LESION IN IVIG-RESISTANT KAWASAKI DISEASE

Background: Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) poses a considerable challenge to patients and their families due to its severe complications.Previous researches have highlighted the critical role of immune disorders in its pathogenesis.However, fragmented studies based on isolated cases hinder a comprehensive understa

OBJECTIVES: Excessive iron can accumulate in the kidney and induce tissue damage.Danshen (Salvia miltiorrhiza) injection is a traditional Chinese medicinal preparation used for preventing and treating chronic renal failure.The aim of the present study was to evaluate the effects of treatment with Danshen injection on iron overload-induced kidney da

Abstract In data assimilation, observations are fused with simulations to obtain an accurate estimate of the state and parameters for a given physical system.Combining data with a model, however, while accurately estimating uncertainty, is computationally expensive and infeasible to run in real-time for complex Flags systems.Here, we present a nove

Recently, the advantages of radial outflow turbines have been outstanding in various operating conditions of the organic Rankine cycle.However, there are only a few studies of such turbines, and information on the design procedure is insufficient.The main purpose of this study is to provide more detailed information on the design methodology of Tro

IgA nephropathy (IgAN) is the most common primary glomerular disease in China and worldwide.The proliferation of B cells is known to be associated with both risk and prognosis of IgAN, but the epigenetic mechanism underlying this association is unknown.In this study we carried out the first Epigenome-wide Association CURRANT CHOCO Study (EWAS) by u